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Alphamine Thermogenic Powder

Alphamine Thermogenic Powder

Regular price $34.99
Regular price Sale price $34.99
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Alphamine is the legendary powdered thermogenic, powered by multiple forms of caffeine, choline, and carnitine. Use Alphamine like an energy drink, or combine it with High Volume on your workout days. At 60 scoops per bottle you won't find a better value, or a more delicious taste. Popular among those looking for daily energy and focus, or used as a pre-workout for those in a leaning-phase of their diet.
  • Gluten Free
  • Third-Party Tested
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  • Thermogenic Energy

    If your goal is sweating during your training, Alphamine will be your go-to pre-workout & energy source. Featuring 2 forms of caffeine + theanine, the energy you feel is smooth and long lasting.

  • TruCarnitine Complex

    Each scoop of Alphamine contains our popular TruCarnitine blend, which is a combination of L-Carnitine-L-Tartrate and Choline. Carnitine helps mobilize long chain fatty acids to be burned in your body, but it needs choline present to do so.

  • Versatile & Stackable

    Alphamine can be used like an energy drink, as a thermogenic pre-workout, and can easily be stacked with our popular caffeine-free pre-workout, High Volume. This stack is known as the ThermoPUMP Stack.

    ThermoPUMP Stack 
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Quality & Purity Testing

All of our raw materials are tested for purity prior to being used in our manufacturing. After manufacturing is complete, another round third-party testing occurs on the finished product before it is released for sale.

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Technical Product Writeup

Maximize Your Workouts and Enhance Metabolism with Alphamine

Pre-workouts help unlock the full potential of your workouts by boosting energy, enhancing the mind-muscle connection, and amplifying muscle pumps.

Now, imagine experiencing these benefits along with fat-burning in mind.

Introducing Alphamine, the premium pre-workout and thermogenic from PEScience.

Dive into the powerful ingredients in every serving of Alphamine and discover how this advanced formula maximizes your workouts and revs up your metabolism to support a fat loss focused diet and exercise program.

Alphamine: What's Under the Lid

Each serving of Alphamine contains six premium, clinically-dosed ingredients intended to maximize workout intensity and boost metabolism.


Carnitine is a compound that helps transport fatty acids into the mitochondria for beta-oxidation to generate energy.

Supplementing with carnitine, however, doesn't necessarily increase carnitine levels or the rate at which fat is transported and burned unless you have a deficiency disease or restrict animal products from your diet, the primary dietary sources.

However, adding choline to the mix can maintain or increase carnitine levels since choline provides essential methyl groups needed to turn lysine into trimethyllysine, which is then converted into carnitine (1, 2).

This is why Alphamine provides both carnitine (as carnitine-L-tartrate) and choline.

To this point, one trial in women demonstrated elevated levels of fatty acid oxidation indicators, which were increased even further with a mild exercise regimen, with choline and carnitine supplementation (3).

A trial in rats suggested greater fat burning with the addition of caffeine to carnitine and choline supplementation, but it's unknown whether these effects translate to humans (3, 4, 5).

Carnitine also plays an important role in regulating pathways involved in skeletal muscle protein breakdown and synthesis and possesses antioxidant and anti-inflammatory properties (6).

Owing to these effects, carnitine supplementation — specifically as the form in Alphamine — can reduce markers of muscle damage in response to exercise, such as myoglobin, creatine kinase, and reactive oxygen species, enhancing the recovery process and blunting declines in strength and power (7, 8).


Next to creatine, caffeine has the most evidence to support its performance-enhancing effects.

Caffeine decreases feelings of pain and exertion during exercise, allowing you to exercise harder than you actually feel. This means you can lift heavier weights, perform more reps, or work out longer before fatiguing (9).

Caffeine also enhances exercise performance by increasing muscular contraction force, alertness, and reaction time through its effects on the central nervous system.

An effective dose ranges between three and six mg per kg (1.4 and 2.7 mg per pound) of body weight before exercise (10).

This range translates to about 200 to 400 mg of caffeine for a 150-pound (68-kg) person.

Each serving of Alphamine provides a perfect middle ground at 300 mg of caffeine as dicaffeine malate. This form is similar to traditional caffeine, but its effects last longer, providing more sustainable energy without the typical caffeine crash.


Theanine is an amino acid found in green and black tea and certain types of mushrooms.

It works synergistically with caffeine to enhance focus and alertness while helping mellow out caffeine's stimulatory effects to provide more sustainable energy (11, 12, 13, 14).

This increased focus and reduction in mind wandering helps you stay zoned in on your workout, improving the amount of volume you can do in a given time and enhancing the mind-muscle connection to achieve better muscle fiber recruitment and muscle pumps (15).


Tyrosine is an amino acid and precursor to the neurotransmitters dopamine and norepinephrine.

Supplementing with tyrosine can enhance cognition and focus during your workouts, especially when levels of these neurotransmitters become temporarily depleted from exercise, stress, or another cause (16, 17).

Some research also suggests that supplementation with tyrosine, caffeine, and theanine may improve multiple aspects of mental and physical performance (18).


Purslane (Portulaca oleracea) is a food and medicinal herb that exhibits strong anti-inflammatory, anti-oxidative, and anti-diabetic activities, in part due to its rich contents of omega-3 fatty acids and flavonoids (19, 20).

Through these activities, purslane can protect and improve endothelial function, a measure of how well the cells that line your blood vessels produce and release compounds like nitric oxide that control blood flow and immune cell activity (21).

Healthier endothelial function ensures better blood and nutrient flow to your muscles during workouts.

Preclinical studies also suggest that purslane has beta-2 adrenergic receptor agonist activity. We do not yet know if these effects translate to humans.

Beta-2 adrenergic receptor agonists promote fat loss primarily by increasing lipolysis and thermogenesis, resulting in the breakdown and utilization of stored fat (24).


6-paradol is the primary bioactive compound found in Aframomum melegueta seeds, a species in the ginger family.

The compound possesses a wide range of bioactivities, including anti-inflammatory, antidepressant, and antimicrobial properties.

Increasing research also suggests that it may have anti-obesity effects through its actions on specific genes related to fatty acid synthesis, lipid transportation, and adipocyte growth.

Another compound present in Aframomum melegueta called 6-gingerol may also contribute to its anti-obesity effects by stimulating AMP-activated protein kinase (AMPK) signaling to increase lipolysis (25).

To these points, a study in overweight men and women found that daily supplementation with a standardized Aframomum melegueta seed extract for 12 weeks increased average energy expenditure by 19% and significantly decreased visceral fat, the more dangerous storage form compared with subcutaneous (26, 27).

Another trial, this time using the same dose found in Alphamine, found similar results in which females who supplemented with it daily for four weeks demonstrated a rise in energy expenditure of nearly 100 calories and a significant decline in visceral fat (28).

Who Can Benefit from Alphamine?

Alphamine is designed for fitness enthusiasts and athletes who seek to maximize their performance and achieve fat loss while preserving lean muscle mass.

Each serving contains carnitine in the form of carnitine-L-tartrate, which helps transport fatty acids into mitochondria for energy production, and choline, which allows carnitine to do this more effectively.

The caffeine in Alphamine, present as dicaffeine malate, provides a sustained energy boost, enhancing exercise performance by decreasing feelings of exertion and increasing alertness. Theanine works synergistically with caffeine to improve focus and reduce the stimulatory effects, promoting more sustainable energy.

Tyrosine, a precursor to dopamine and norepinephrine, enhances cognition and focus, especially during high-intensity workouts.

Purslane, with its potential beta-2 adrenergic receptor agonist activity, increases lipolysis and thermogenesis, supporting fat loss, while its antioxidant properties improve endothelial function and nutrient flow to muscles.

6-paradol from Aframomum melegueta seeds further promotes fat loss by activating certain genes involved in fat metabolism, while another compound found in the seeds called 6-gingerol may stimulate AMPK signaling to increase lipolysis.

Alphamine's advanced formula supports an increased metabolism through these synergistic ingredients, offering a comprehensive solution for those looking to elevate their workout performance and achieve their fitness goals.

How to Take Alphamine

Each tub of Alphamine provides 30 two-scoop servings.

It's available in four delicious flavors, including, Black Cherry, Sour Green Apple, Raspberry Lemonade, and Melon Berry Twist.

Mix one to two scoops of Alphamine with six to eight ounces of water 30-60 minutes before your workout. Remember to stay hydrated before, during, and after your workouts while taking this product.

To assess your tolerance, you can start with one scoop and work up to two scoops.

You can also use Alphamine like an energy drink or combine it with PEScience's popular caffeine-free pre-workout, High Volume, for stronger muscle pumps, enhanced performance, and hydration benefits.

The Bottom Line

Alphamine is designed for fitness enthusiasts and athletes who seek to maximize performance and achieve fat loss while preserving lean muscle mass.

Each serving contains carnitine-L-tartrate, which transports fatty acids into mitochondria for energy production, and choline, which increases carnitine's effectiveness.

The caffeine provides sustained energy, while theanine smooths its stimulatory effects, improving focus. Tyrosine enhances cognition and focus during workouts, while purslane increases lipolysis and thermogenesis, supporting fat loss and improving nutrient flow to muscles.

Additionally, 6-paradol promotes fat loss through its action on specific genes that regulate fat metabolism.

Alphamine's advanced formula supports increased metabolism through these synergistic ingredients, offering a comprehensive solution for enhanced workout performance and fat loss.


Gavin Van De Walle, MS, RD

Gavin Van De Walle holds a master’s degree in human nutrition and exercise physiology. He is also a registered dietitian. Gavin has a bias for the truth and aims to provide the public with the information they need to make educated and informed health decisions. His work has appeared in a variety of publications, including Healthline, Livestrong, the American Botanical Council, Underwriter Laboratories, Verywell Health, and many more.