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Power Up Your Performance: Discover How Prolific Sets the Standard in Pre-Workouts

Next to protein powders, pre-workouts are among the most popular sports supplements.

Pre-workouts are generally stimulant-based to provide an acute energizing effect but they also contain other ingredients intended to enhance focus and blood flow to working muscles.

Despite their popularity and ubiquity, not all pre-workout products are created equal, with many using inferior or inadequately dosed ingredients.

Recognizing the need for a pre-workout that delivers on its promise, PEScience has crafted Prolific with high-quality, clinically-dosed ingredients to help its users get more from their workout.

Learn how Prolific distinguishes itself from other pre workouts.

Prolific: What's Under the Hood

Prolific contains eight carefully picked ingredients intended to amplify energy, sharpen focus, and deliver powerful muscle pumps.

Here's a closer look at each:

Citrulline

Citrulline is an amino acid and precursor to another amino acid called arginine.

Arginine is commonly included in pre-workouts since it directly produces nitric oxide, an important molecule that relaxes the inner muscles of the blood vessels, causing them to widen and increase circulation.

However, arginine is subject to first-pass metabolism by the intestines and liver, meaning a large percentage of it is broken down before it gets a chance to reach the bloodstream.

On the other hand, citrulline is not subject to this same fate and actually inhibits the enzyme that breaks down arginine.

For this reason, citrulline supplementation increases arginine levels in the body more than supplementing with arginine itself and is therefore much more effective for increasing nitric oxide (1).

To this point, dozens of clinical studies have demonstrated that citrulline supplementation at or below the dose provided in Prolific can delay muscle fatigue and increase endurance during high-intensity strength training, with other studies demonstrating improved post-exercise muscle recovery (2, 3, 4).

Betaine

Betaine — or trimethylglycine (TMG) — is an anti-inflammatory and antioxidant compound.

It was first isolated from beets Beta vulgaris, from which it's named.

Betaine sustains cell hydration and function in response to various physiological stressors — including exercise — increases free choline thereby potentially increasing acetylcholine production to support muscle contractions, and may influence certain additional mechanisms leading to downstream muscle growth (5, 6, 7).

Through these actions, studies have shown that supplementation with 2.5 grams of betaine — the dose provided in Prolific — daily for around two weeks significantly improves muscle strength, reduces muscle fatigue, and improves body composition (8, 9, 10, 11).

Taurine

Taurine is an amino acid heavily concentrated in the brain, heart, and skeletal muscles.

Despite the common belief, taurine does not come from bull semen or urine, but it was first isolated from the bile of an ox. Bos taurus, the Latin name for an ox, is where its name originated.

By maintaining proper hydration and electrolyte balance in cells, regulating levels of minerals necessary for muscle contractions within your cells like calcium, and through its antioxidant function, taurine supplementation may improve exercise performance and decrease exercise-induced muscle damage and oxidative stress (12, 13, 14, 15).

Other research suggests that taurine supplementation can improve lipid metabolism with exercise by affecting genes related to mitochondrial activity and fatty acid oxidation as well as improve thermoregulatory capacity during exercise in hot conditions (16, 17).

These benefits have been demonstrated using the same dose found in Prolific.

Caffeine

Caffeine is the star of nearly all pre-workouts — but for good reasons.

Dozens of clinical studies have demonstrated that caffeine ingestion significantly enhances muscle endurance, strength, and power in several ways, including intracellular calcium release in muscle cells to increase muscle force, preservation of muscle glycogen, and antagonistic action to adenosine's depressant effects in the brain (18).

Caffeine can also improve mood and measures of cognitive functions like attention when consumed before exercise (19).

Caffeine tends to be most beneficial for improving exercise performance when consumed at a dose of three to six milligrams per kilogram of body weight (20).

This translates to 200 to 400 mg of caffeine for a 150-pound (68-kg) person.

Prolific provides 320 coming from two caffeine sources, caffeine anhydrous and dicaffeine malate.

Theanine

Theanine is an amino acid found primarily in green and black tea and certain types of mushrooms.

When taken together, caffeine and theanine offer synergistic effects, significantly helping to improve cognitive performance and mood more than either compound alone (21, 22, 23).

Theanine mellows out the stimulatory effects of caffeine, helping to "take the edge off" by increasing the alpha frequency band in the brain to relax the mind but without inducing drowsiness (24).

Citicoline

Citicoline is a precursor to phosphatidylcholine, a major cell membrane phospholipid that supports the production of adenosine triphosphate (ATP) or energy in the brain to maintain focus.

Heightened focus during workouts supports the mind-muscle connection or the ability to focus on and deliberately contract a specific muscle or muscle group.

While "bro-sciencey" sounding, actively focusing on the muscle squeeze and contraction during lifts has been shown to increase muscle fiber recruitment and activation, supporting greater gains in muscle and strength (25, 26, 27).

Rhodiola

Rhodiola (Rhodiola rosea) is an herb that has a long history of use in traditional medicine for increasing endurance and work performance, and to manage fatigue, weakness, and other symptoms (28).

It's categorized as an adaptogen, meaning it increases the body's resilience to stress in nonspecific ways.

Through its adaptogenic properties, rhodiola supplementation has been shown to improve antioxidant activity and reduce muscle fatigue and post-exercise muscle soreness and damage (29, 30).

Coffee fruit extract

Coffee fruit extract, as the name suggests, comes from the fruit of the coffee plant.

It's rich in chlorogenic acids and other polyphenols that offer potent antioxidant and anti-inflammatory effects.

The extract has been shown to boost brain-derived neurotrophic factor (BDNF), a protein important for learning, memory, and glucose metabolism, among many other functions (31).

Who Can Benefit from Prolific?

Anyone who demands more from their workout can benefit from Prolific.

Unlike other popular pre workouts, Prolific contains only ingredients in clinically-backed doses that have an acute or immediate effect on workout performance.

Thanks to dicaffeine malate and theanine, you get all the benefits of a high caffeine dose without the crash, digestive issues, jitters, or anxiety.

Additionally, Prolific is packed with six grams of citrulline to support nitric oxide production for easier and better muscle pumps, betaine to strengthen muscle contractions, and taurine to support cellular hydration and antioxidant status.

Finally, with premium ingredients like citicoline, rhodiola, and coffee fruit extract, you can expect a better mind-muscle connection and reduced muscle fatigue.

How to Take Prolific

Each container of Prolific contains 20, two-scoop servings.

Choose from eight, delicious flavors:

• Guava Pineapple Punch
• Melon Berry Twist
• Sour Peach Candy
• Raspberry Lemonade
• Mango Splash
• Sour Green Apple
• Black Cherry
• Strawberry Kiwi

Mix two scoops with 8–10 ounces (250–300 mL) of cold water and consume before your workout, ideally within 30 minutes.

If you're sensitive to caffeine, it's best to start with one scoop to assess your tolerance.

The Bottom Line

PEScience's Prolific Pre Workout Prolific stands out in the crowded pre workout supplement market with eight scientifically-backed ingredients designed to optimize energy, focus, and muscle pumps.

It not only provides a substantial boost to workout performance through ingredients like citrulline and betaine but also avoids the common post-caffeine crash and other adverse effects of a high caffeine dose thanks to dicaffeine malate and theanine.

Additionally, the inclusion of compounds such as taurine and citicoline supports better muscle function and cognitive focus, making Prolific an excellent choice for anyone looking to maximize their workout efficiency and results.

With clinically dosed, premium ingredients, Prolific promises more than just immediate energy, offering sustained performance benefits and improved recovery.

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Gavin Van De Walle, MS, RD

Gavin Van De Walle holds a master’s degree in human nutrition and exercise physiology. He is also a registered dietitian. Gavin has a bias for the truth and aims to provide the public with the information they need to make educated and informed health decisions. His work has appeared in a variety of publications, including Healthline, Livestrong, the American Botanical Council, Underwriter Laboratories, Verywell Health, and many more.